BRUSSELS—Alphabet Google lost most of its appeal to overturn a $4.33 billion antitrust decision imposed by the European Union for allegedly using its Android operating system to squash competition—but got a roughly $215 million reduction in the fine.

The ruling on Wednesday is a vote of confidence for the European Commission, the bloc’s antitrust enforcer, which has been aggressive in targeting big U.S. tech companies over concerns about anticompetitive behavior. The Android case was the biggest of three antitrust fines totaling more than $8 billion that the Commission has levied against Google since 2017—and it focused on mobile phones, one of the company’s fastest growth areas.

This post first appeared on wsj.com

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