Big Pharma loves political gridlock. In fact, shares of pharmaceutical and biotechnology companies tend to outperform the broader market when Congress is divided.

With Republicans poised to flip control of the House in the midterm elections and President Biden’s “Build Back Better”—which included drug pricing reform—on life support, it seemed Big Pharma would soon be in the clear on tough action coming out of Washington.

SHARE YOUR THOUGHTS

Should the government be able to negotiate drug prices for Medicare recipients? Why or why not? Join the conversation below.

But West Virginia’s Democratic Sen. Joe Manchin, who doomed the $1.7 trillion spending bill in December, is now giving advocates of reform a smidgen of hope by lending his support to a slimmed-down version of the legislation that could include provisions to lower drug prices. Mr. Manchin may be no fan of big spending bills, but he can’t ignore retirees in West Virginia who pay 10 times more than their counterparts in other rich countries for insulin.

Drug pricing “is something we all agree on,” Mr. Manchin said at an AARP event, adding “if we do nothing more this year, that’s the one thing that must be done.”

Mr. Manchin has been quietly negotiating with Senate Majority Leader Chuck Schumer (D., N.Y.), and the talks are serious enough to alarm Wall Street. Brian Abrahams, an analyst at RBC Capital, thinks the risk of “drug pricing legislation making a comeback is highly underappreciated on the Street.’’ A group of Morgan Stanley analysts, including Matthew Harrison and Terrence Flynn, noted that with “midterm elections nearing, Democrats appear ready to take one more serious shot’’ at lowering prescription drug prices.

A lobbyist representing large healthcare providers estimates the chance of a bill passing at 50%. Still, he warned that while Arizona’s Sen. Kyrsten Sinema —another pivotal Democrat—ultimately agreed to drug-pricing provisions in the original Build Back Better legislation last year, she might not be a fan of a stripped-down version of the legislation that solely goes after the drug industry. Mr. Manchin, on the other hand, is signaling that he would be up for that.

He has said that the deadline to pass a spending bill is Sept. 30, the end of the federal government’s fiscal year. Any progress in negotiations this summer could put some pressure on sector stocks—especially those with the most exposure to the bill, such as big biotechs Regeneron REGN 4.40% and Amgen. AMGN 1.83% Direct Medicare negotiations for Regeneron’s Eylea could trim the company’s revenue by 5% to 15%, according to Morgan Stanley estimates.

While details of a slimmed-down version of the Build Back Better bill aren’t known, the measure would likely address climate change and drug pricing, borrowing elements from last year’s bill. That means direct Medicare negotiation for a list of drugs and capping out-of-pocket costs could make it in. Support from all 50 Democratic senators would be crucial to bypass a GOP filibuster in the Senate via the reconciliation process.

There is a good amount of skepticism. Mr. Manchin told Axios that, while the talks are respectful, there “could be nothing” there. “Manchin and Schumer have been down this road several times without success,” Rick Weissenstein from Cowen wrote in a note last week.

Drug prices remain out of reach for many Americans, who pay among the highest prices in the world. In an interview with WSJ, billionaire investor Mark Cuban explains how his low-cost, online drug company works and the challenges it faces in a consolidated industry. Photo illustration: Adele Morgan/Storyblocks

If nothing is passed by the time the Senate goes into recess in August, investors will start feeling more comfortable upping their pharma and biotech bets in anticipation of a poor showing for Democrats in the fall. And even if a bill does pass, it will chop at most a few percentage points from industry sales as a whole, so executives aren’t in panic mode.

For now, though, Joe Manchin is one of the most powerful men in Washington and one to watch on Wall Street as well. Until it is clear where he stands, healthcare investors shouldn’t let their guards down.

Write to David Wainer at [email protected]

Copyright ©2022 Dow Jones & Company, Inc. All Rights Reserved. 87990cbe856818d5eddac44c7b1cdeb8

This post first appeared on wsj.com

You May Also Like

Roblox Shares Jump in Public-Markets Debut

Shares of Roblox Corp. RBLX 55.07% jumped as much as 66% Wednesday…

House Speaker Mike Johnson meets with Trump after giving 2024 endorsement

House Speaker Mike Johnson, who recently made clear his endorsement of Donald…

SEC to Vote on Rule to Claw Back Executive Pay

Markets Financial Regulation Under rule, companies would have to recoup incentive pay…

Murdaugh trial blog

Murdaugh murder trial live updates: Suspect continues testimony IE 11 is not…