Holmes, who was charged with defrauding investors in her blood-testing start-up, hoped to stay out of jail while she appealed her conviction

Theranos founder Elizabeth Holmes must begin serving her prison sentence while she appeals against her conviction on charges of defrauding investors in her failed blood-testing startup and must jointly pay $452m in restitution to the victims of her crimes, a court in San Francisco has ruled.

Holmes, who rose to fame after claiming Theranos’ small machines could run an array of diagnostic tests with just a few drops of blood, was convicted at trial in San Jose, California, in 2022 and sentenced to 11 years and three months in prison.

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