US president to meet only Israeli figures on Wednesday after Jordan summit cancelled and protests spread across the Middle East

A deadly blast at a hospital in Gaza City has upended US diplomatic efforts aimed at fending off the humanitarian disaster in Gaza and thrown a dark shadow over president Joe Biden’s imminent visit to the region.

Late on Tuesday, Jordan cancelled a summit in Amman in which Biden had been due to hold talks with King Abdullah, the Egyptian president Abdel Fatah al-Sisi and Palestinian Authority president Mahmoud Abbas. The cancellation came as the US president was en route to Israel for talks with Benjamin Netanyahu on Wednesday morning.

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