WASHINGTON—Sen. Elizabeth Warren’s opposition to President Biden’s renomination of Federal Reserve Chairman Jerome Powell marks her most public break with her one-time presidential rival, whose economic policy and personnel choices she has helped shape.

Ms. Warren said Monday that she would vote against Mr. Powell’s nomination for a second term as Fed chairman, a move that was widely expected after she assailed Mr. Powell in September as a dangerous man who would weaken banking rules. She announced her support for Fed governor Lael Brainard, who was nominated to serve as Fed vice chairwoman.

This post first appeared on wsj.com

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