The once lucrative heart-drug market is now poised to make a comeback, but at the cost of heavy investments in research and deal making.

After watching lower-priced generics seize sales of once-highflying blood-pressure, cholesterol and other heart drugs, companies struggled to discover replacements and then win reimbursement for five-figure prices. Drugmakers are now rolling out new medicines, though their commercial prospects are uncertain.

This post first appeared on wsj.com

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